BookThemes are a new way to create and adapt books for different styles and sizes. Think of BookThemes as like templates but better!
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Because the reader is unable to influence the text presentation of the fixed layout EPUB in the same way as a reflowable EPUB (such as font style and size), general good practice for print graphic design and for web UX apply in fixed layout EPUB.
Classic graphic design consideration such as grids, white space, complimentary font combinations, line length, leading and tracking and so on become more important.
A good article on the subject is Read Between The Lines: Why Legibility And Readability Is Essential For UX.
General good practice for print graphic design can carry though to ebook design too.
